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What side effects may I notice from Nexavar?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using sorafenib and call your doctor at once if you have:

  • mouth sores;

  • blood in your urine or stools, coughing up blood or vomit that looks like coffee grounds;

  • heavy menstrual periods, easy bruising, unusual bleeding, or any bleeding that will not stop;

  • pale skin, feeling light-headed, rapid heart rate, trouble concentrating;

  • dry cough, wheezing;

  • chest pain and severe dizziness, fainting, sweating, swelling, rapid weight gain, feeling short of breath (even with mild exertion);

  • rash, blisters, oozing, or severe pain in the palms of your hands or the soles of your feet;

  • upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

  • sudden weight loss, increased appetite, trouble sleeping, increased bowel movements, feeling hot, feeling nervous or anxious, swelling in your neck (goiter);

  • dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, confusion, uneven heartbeats, seizure); or

  • severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Common side effects may include:

  • tired feeling;

  • vomiting, diarrhea, mild stomach pain;

  • mild itching or rash; or

  • weight loss, thinning hair.

This is not a complete list of side effects and others may occur.

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